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KMID : 0984720060380050259
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Infection and Chemotherapy
2006 Volume.38 No. 5 p.259 ~ p.265
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Immunogenicity and Safety of Half Does Intradermal Injection Compared to Full Dose Intramuscular Injection of Influenza Vaccine in Healthy Adults
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Jo Yu-Mi
Kee Sae-Yoon
Song Joon-Young
Choi Won-Suk
Kim Jeong-Yeon
Seo Yu-Bin
Jeong Hye-Won
Kim Woo-Joo
Cheong Hee-Jin
Kim Sung-Ran
Hwang In-Suk
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Abstract
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Background : Influenza is the representative respiratory infectious disease causing significant high
morbidity. Vaccination is the most effective method to prevent influenza. To cope with both unstable
supply and increasing demand of influenza vaccine with more flexibility, we studied the safety and
immunogenicity of half dose intradermal injection of influenza vaccine in healthy adults compared with
full dose intramuscular injection method.
Materials and Methods : We conducted a randomized, open-label trial in healthy adults of age 15 to
64 years. Subjects were randomly assigned to receive either a recommended dose of influenza vaccine
(Fluarixⓡ, Injection Prefilled Syringe, GlaxoSmithKline, hemagglutinin antigen (HA) 15 μg) via intramuscular
route (designated as control group) or a half recommended dose (HA 7.5 μg) via intradermal
route (designated as experimental group). Blood samplings were done before and more than 28 days
after vaccination. We measured the changes in hemagglutination-inhibition (HAI) antibody titers and
compared geometric mean titers, seroconversion rates, seroconversion factors and seroprotection rates
of each group. Local and systemic adverse events were assessed after vaccination.
Results : In antibody titer against all three antigens (A/H1N1, A/H3N2, B) was more evident in
intramuscular injection group but intradermal group with half dose showed acceptable immunogenicity
fulfilling criteria for Committee for Proprietary Medicinal Products (CPMP). Likewise, seroprotection
rates for all three viral strains showed no significant difference between the two groups. Although
local reactions were significantly more frequent and lengthy in intradermal group than in intramuscular
group, the reactions were mild and transient.
Conclusion : Compared with intramuscular injection of full dose influenza vaccine, intradermal
injection of half dose resulted in comparable immunogenicity in healthy adults. Intradermal administration
of half dose influenza vaccine could be a practical alternative plan to expand the supplies of
influenza vaccine, but further studies will be needed in high risk groups.
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KEYWORD
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Influenza Vaccine, Intradermal Injection, Intramuscular Injection
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